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Magnesium, B Vitamins and Co.: What Helps with Stress?

June 6, 2025Timo HarbeckeReading time: 3,1 Minuten

Stress is everywhere – at work, in everyday life or as a result of inner, physical strain. Even though stress can be useful in the short term, in the long run it has a negative effect on body and mind and can throw your inner balance off kilter.

This is exactly when it is worth paying attention to a balanced supply of important nutrients. Magnesium and various B vitamins, for example, play an important role for your nervous system: magnesium contributes to normal functioning of the nervous system and to normal psychological function. Biotin also contributes to normal functioning of the nervous system and to normal psychological function.

In addition, the connection between the gut and the brain is increasingly coming into focus. The two are in complex communication via the so-called gut-brain axis, which also involves the gut microbiome – the trillions of microorganisms that colonise the human digestive tract.

In this article, you will find out which nutrients are particularly interesting in stressful times and what role the gut and the gut microbiome play.

Magnesium for Stress: The Calming Force for Your Nervous System

Magnesium-rich foods: white beans, lentils, seeds and millet in coconut bowls, with almonds, spinach, broccoli and green beans

Magnesium is one of the most important minerals when it comes to stress – and at the same time one of the most underestimated. It is involved in more than 300 different processes and metabolic reactions, contributes to normal functioning of nerves and muscles and helps the body to relax and recover. However, as more magnesium is used up during psychological strain, a deficiency can develop. Possible consequences include: nervousness, muscle tension, inner restlessness.

Our Pro Magnesium combines magnesium L-lactate with magnesium pidolate and magnesium bisglycinate, providing a particularly good supply with high bioavailability at the same time. The mineral acts like a natural buffer in stressful times and can help your body to wind down better in the evening.

Our tip: Taking magnesium regularly in the evening is also worthwhile if you have trouble sleeping.

Gut Bacteria Against Stress: Why the Gut-Brain Axis Matters

Woman in a white blouse lying relaxed on a blanket on the grass in a park by a lake

Your gut and your brain are in constant communication – and only around 10 % of the signals travel from the brain to the gut, while about 90 % travel from the gut to the brain. Via the so-called gut-brain axis, your mood, your stress level and even your behaviour are significantly influenced. Stress has a negative effect on the gut flora, and at the same time a disturbed microbiome can further intensify stress.

Our Pro Biom Anti-Stress contains selected bacterial strains such as Lactobacillus helveticus Rosell®-52 and Bifidobacterium longum Rosell®-175 (CEREBIOME®), complemented by saffron extract (Safr’Inside™) and biotin. Biotin contributes, among other things, to normal functioning of the nervous system and to normal psychological function. Pro Biom Anti-Stress thus brings together selected bacterial cultures, saffron and biotin in a carefully balanced combination.

You can read more about the gut-brain axis in this blog article.

B Vitamins, Plant Extracts & Co.: Brain Food in Stressful Times

Man in a grey T-shirt drinking a green smoothie from a glass in the kitchen

Especially in stressful and demanding times, it is worth paying attention to a balanced supply of important micronutrients, because vitamins and minerals perform numerous functions in the body – including for the nervous system, mind, energy metabolism and cell protection.

A brief overview of important nutrients for stress:

  • Magnesium contributes to normal muscle function and normal functioning of the nervous system, regulates stress hormones and, with an adequate intake, can help you to sleep better.
  • B vitamins (especially biotin) are important for energy production, nerve function and psychological resilience.
  • Vitamin C contributes to the normal function of the immune system, plays an important role in the regulation of cortisol and contributes to the protection of cells from oxidative stress.
  • Zinc contributes to the normal function of the immune system and to the protection of cells from oxidative stress.
  • Potassium contributes to normal functioning of the nervous system and to normal muscle function and has a balancing effect.
  • Coenzyme Q10 and phytonutrients (especially polyphenols) complement the supply of selected micronutrients and plant compounds.

A regular supply of these nutrients – both during stressful periods and as a preventive measure – is a strong foundation for everyday life. You will find them in our Nutrient Package Basic with Pro Multivitamin Complete and Pro Mineral Complete – including the package discount.

Conclusion: Targeted Use of Nutrients for Stress

Pro Biom Anti-Stress, Pro Magnesium and Pro Somnia Relax from the Anti-Stress Package with three capsules in front of a light stone background

Our Anti-Stress Package combines selected bacterial cultures, plant extracts and micronutrients, including magnesium and B vitamins such as biotin for normal functioning of the nervous system and normal psychological function:

  • Pro Biom Anti-Stress – with selected bacterial cultures, saffron extract (Safr’Inside™) and biotin
  • Pro Magnesium – high-quality magnesium powder with three organic forms of magnesium: magnesium L-lactate, magnesium pidolate and magnesium bisglycinate
  • Pro Somnia Relax – with patented asparagus extract (ETAS®50), milk protein hydrolysate (Lactium®) and magnesium

The Anti-Stress Package Plus also contains:

  • Pro Omnineuro – with L-carnosine, taurine, quercetin, selected plant extracts and the vitamins B6, B12 and folic acid

Complementary basic supply: the Nutrient Package Basic

  • Pro Multivitamin Complete – with all vitamins (A, C, D3, E, K1, K2 and the B complex), choline, inositol, betaine, coenzyme Q10, a polyphenol complex (VitAlign™) as well as lutein and zeaxanthin
  • Pro Mineral Complete – with 11 important minerals in a highly bioavailable form, including calcium and magnesium in the evolutionary 1:1 ratio

Sources

  • Franco R, Martínez-Pinilla E. Chemical rules on the assessment of antioxidant potential in food and food additives aimed at reducing oxidative stress and neurodegeneration. Food Chemistry, 2017. https://pubmed.ncbi.nlm.nih.gov/28554642/
  • Krenek AM, Aggarwal M, Chung ST, Courville AB, Farmer N, Guo J, Mathews A. Influence of a Virtual Plant-Based Culinary Medicine Intervention on Mood, Stress, and Quality of Life Among Patients at Risk for Cardiovascular Disease. Nutrients, 2025. https://europepmc.org/article/MED/40284222
  • Sporea C, Morcov MV, Vasile CI, Cioca IE, Apostol OA, Mirea A, Punga A. The Interplay Between Stress and Eating Attitudes: A Cross-Sectional Study Among Romanian Physical Therapy Students. Journal of Clinical Medicine, 2025. https://europepmc.org/article/MED/40095861

Frequently asked questions

Especially in stressful times, it is worth paying attention to a balanced supply of important nutrients. Magnesium and various B vitamins contribute, among other things, to normal functioning of the nervous system and to normal psychological function. In addition, selected plant compounds and bacterial cultures can complement your daily supply. TISSO’s Anti-Stress Package and Anti-Stress Package Plus offer a carefully balanced combination of these ingredients.

In addition to a good supply of nutrients and psychobiotics, relaxation techniques such as meditation, yoga or breathing exercises, regular exercise, sufficient sleep and conscious breaks in everyday life can help. A nutrient-rich diet provides additional support for the body in stressful times.

The gut and the brain are in complex, two-way communication via the so-called gut-brain axis. The gut microbiome is also part of this interplay. At the same time, persistent stress can affect the gastrointestinal tract and the gut microbiome.

Pro Biom Anti-Stress combines selected bacterial cultures with saffron extract and biotin. Biotin contributes to normal functioning of the nervous system and to normal psychological function. If you would also like to give your gut flora targeted support with selected bacterial cultures, dietary fibre and nutrients for the mucous membranes, the Probiotics Gut Cure Original offers a combination tailored to exactly that.

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