Pro Melatonin Depot—Packaging
Easy to use Pro Melatonin Depot: 2 capsules per day; open hand holding capsules. Tip for swallowing, the “nod trick”: 1. Place the capsule on your tongue, 2. Take a sip of water, 3. Tuck your chin toward your chest, 4. Swallow
Pro Melatonin Depot, in a jar in front of chamomile flowers; features: monthly supply, gluten-free, lactose-free, fructose-free
What sets Pro Melatonin Depot apart? A depot formula for immediate and sustained release, with chamomile flower extract and reishi; high-quality ingredients with no additives—conventional product: contains only fast-release melatonin, no plant-based ingredients, low-quality ingredients, and additives
vegan
fructose-free
lactose-free
gluten-free
yeast-free
Tested for harmful substances

DIETARY SUPPLEMENTS

Pro Melatonin Depot

4.8 (19)

Rediscover your natural sleep rhythm—with Pro Melatonin Depot. Extended-release melatonin combined with chamomile and reishi helps you drift off gently and sleep soundly through the night.

  • Top Sleep Combination: Extended-release melatonin plus chamomile flowers & reishi
  • Extended-release melatonin (melotime™): released immediately and over several hours 
  • plus chamomile flower extract & reishi powder—traditionally used for relaxation 
  • Improved ability to fall asleep and stay asleep, plus alertness the next day
  • helpful for sleep rhythm disruptions caused by jet lag, shift work, etc.
  • Recommended supplement: Anti-Stress Package or Anti-Stress Package Plus
vegan
fructose-free
lactose-free
gluten-free
yeast-free
Tested for harmful substances

26,95 €

Choose your volume discount:

Volume discounts cannot be combined with subscription plans.

26,95 €

Content: 20 g | 1 kg = 1.347,50 €
Tax included and shipping calculated at checkout

26,95 € 25,60 €

Product available – delivered to you in 1–4 daysfrom 0,90 € per dayCapsules: 20 g = 60 capsulesAvailable through a savings planin-house development
Developed in collaboration with therapists

Over 8,000 doctors and naturopaths
. See what the therapists have to say

PZN:19968922

Delivery to Switzerland is not available.

Health-related claim:

  • Melatonin helps reduce the time it takes to fall asleep. The beneficial effect occurs when 1 mg of melatonin is taken shortly before bedtime.
  • Melatonin helps alleviate the subjective symptoms of jet lag. The beneficial effects are felt when at least 0.5 mg of melatonin is taken shortly before bedtime on the first day of travel and during the first few days after arriving at the destination.

It is recommended to take 2 capsules daily with plenty of water about 30–60 minutes before bedtime.
Do not exceed the recommended daily intake.

Notes:
Dietary supplements should not be used as a substitute for a balanced and varied diet and a healthy lifestyle.
Store in a cool, dry place away from light.
Keep out of the reach of small children.
Please leave the desiccant packet in the can. It contains food-grade silica gel and protects the product from moisture.

Special Notes:
Not suitable for pregnant women, nursing mothers, or people under 18 years of age.

Ingredientsper daily dose
Melatonin (melotime™)1.9 mg
Chamomile flower extract200 mg
Reishi powder200 mg

Ingredients:

Chamomile flower extract (28.8%); reishi powder (Ganoderma lucidum) (28.8%); pullulan; rice flour; melatonin (0.6%)

No flavor enhancers, preservatives, or artificial colors.
melotimeTM is a trademark of Nutriventia Ltd.

Toxic Substance Analyses by Independent Laboratories

Quality and safety are TISSO’s top priorities. That’s why we have our products regularly tested by independent laboratories. 

These contaminant analyses ensure that our products consistently meet the highest quality standards. For Pro Melatonin Depot, you can download the analysis results from a DAkkS-accredited laboratory.

Download Analysis Confirmation

Download Test Report

Your legal guarantee rights
LEGAL GUARANTEE Minimum two-year legal guarantee protection for goods sold in the European Union. Consumers can claim their rights under the legal guarantee of conformity, for example if goods: do not match the description; do not function as intended. Sellers are liable for any lack of conformity which existed when the goods were delivered, and which becomes apparent within the legal guarantee period. Sellers in such a situation are required to offer: free repair or free replacement; in some cases, a price reduction or full reimbursement. Some countries have a longer legal guarantee period. For second-hand goods, a shorter period may apply, but not less than one year. For more information on your rights in a specific country, scan the QR code below or ask the seller. europa.eu/youreurope/guarantees What to do if you receive non-conforming goods: 1 Contact the seller as soon as possible to report the issue; 2 Provide proof of purchase, such as a receipt, invoice, or bank statement. Sellers and producers may also offer commercial guarantees, which apply independently from the legal guarantee. For example, you may see this GARAN label representing a commercial guarantee of durability offered by the producer at no additional cost and covering the entire good.

Open the legal guarantee notice on Your Europe

NATURE AND RESEARCH EFFECTIVELY COMBINED
From practice for people.
NATURAL DIETARY SUPPLEMENTS FOR YOUR HEALTH
Lächelnde Frau entspannt im Bett nach erholsamem Schlaf
Lächelnde Frau entspannt im Bett nach erholsamem Schlaf

Melatonin – Gentle Support for Falling Asleep

Melatonin is a hormone produced naturally by the body that is released in greater quantities when it gets dark and signals to our body that it is time to sleep. However, stress, jet lag, or shift work can throw this natural regulation out of balance—making it harder to fall asleep and disrupting our sleep cycle.

Pro Melatonin Depot Contains high-quality melatonin in the innovative melotime™ formulation, which ensures an immediate yet sustained release over several hours. Conventional melatonin causes levels in the body to rise rapidly and then drop just as quickly. According to studies, however, the sustained-release technology works differently: it ensures a slower rise and a more even release throughout the night¹. This not only makes it easier to fall asleep but also promotes uninterrupted sleep—an important factor in achieving good sleep quality.

Nahaufnahme von blühenden Kamillenblüten mit weiß-gelben Blütenköpfen
Nahaufnahme von blühenden Kamillenblüten mit weiß-gelben Blütenköpfen

Chamomile and Reishi—Natural Allies for Restful Nights

In addition to sustained-release melatonin, Pro Melatonin Depot contains two natural ingredients that gently promote the transition to sleep: chamomile flower extract and reishi powder.

Chamomile (Matricaria recutita) It is one of Europe’s best-known and most time-honored medicinal plants. Its flowers contain flavonoids and terpenoids—specific phytochemicals—and act through the GABAA receptor, a key regulatory point for relaxation and inner calm. In studies, chamomile flower extract has been shown to significantly improve sleep quality, the time it takes to fall asleep, and overall rest—while also reducing the number of nighttime awakenings.2

The reishi mushroom (Ganoderma lucidum), Also known as “Ling Zhi” or glossy lacquer mushroom, it has been valued in Asia for thousands of years for treating sleep problems. Its relaxing effect is also associated with GABAA receptor activity. Animal studies have shown that reishi can both shorten the time it takes to fall asleep and extend sleep duration.3,4 Together, chamomile and reishi form an evening herbal formula that gently helps the body and mind wind down.

Sources

1 Seiden et al. A Randomized, Crossover, Pharmacokinetic Evaluation of a Novel Continuous-Release and Absorption Melatonin Formulation. Prim Care Companion CNS Disord. Aug. 1, 2019;21(4):19m02450.

2 Adib-Hajbaghery et al. The effects of chamomile extract on sleep quality among elderly people: A clinical trial. Complement Ther Med. Dec 2017;35:109-114. doi: 10.1016/j.ctim.2017.09.010.

3 Yao et al. Ganoderma lucidum promotes sleep through a gut microbiota-dependent pathway involving serotonin in mice. Sci Rep. July 1, 2021;11(1):13660. doi: 10.1038/s41598-021-92913-6.

4 Chu et al. Extract of Ganoderma lucidum potentiates pentobarbital-induced sleep via a GABAergic mechanism. Pharmacol Biochem Behav. April 2007;86(4):693-8. doi: 10.1016/j.pbb.2007.02.015.

TESTIMONIALS FROM TISSO PARTNERS

Portrait photo of Iwonna Riesenfeld, a naturopath from Düsseldorf
Iwonna Riesenfeld, naturopath
Düsseldorf


“I’ve been working as a naturopath for 15 years, and I’ve been recommending TISSO products for just as long. What continues to impress me time and again is the outstanding quality and the well-thought-out formulation of each product. What’s also worth highlighting is that the products are based on the latest scientific findings and take into account the company’s own studies and observational data.”

Portrait photo of Joachim Fehrenbacher, a physical therapist from Schramberg
Joachim Fehrenbacher, Physical Therapist
Schramberg


"Since we take a holistic approach to caring for people, we really enjoy working with TISSO’s highly effective products. A trusting partnership of this kind is possible with only a few companies."

Portrait photo of Ailyn Moser, a naturopath from Radolfzell on Lake Constance
Ailyn Moser, naturopath
Radolfzell on Lake Constance


“As a naturopath, I greatly value my collaboration with TISSO, as their work focuses on both our microbiome and our mitochondria. Their holistic dietary supplements combine active ingredients from orthomolecular medicine, phytotherapy, and mycotherapy. For me, TISSO is a reliable partner that supports my patients’ health.”

Portrait photo of Nicole Bode, a naturopath from Höxter
Nicole Bode, alternative medicine practitioner
Höxter


“Products that aren’t just good for my patients, but that I also trust. At TISSO, they take the time to provide detailed advice, which is why I could never do without this partnership! A wide variety of products from naturopaths for naturopaths, where you can be sure that people’s well-being comes first—not money. I’m happy to stay here and can only recommend it to others!”

Portrait photo of Andreas Klose, a naturopath from Potsdam
Andreas Klose, Alternative Medicine Practitioner
Potsdam


"I've been a naturopath for twenty years and have been working with TISSO products for over seven years. What pleases me most is receiving positive feedback from patients and seeing the results reflected in their test results."

Portrait photo of Sandra Oettel, a naturopath from Trier
Sandra Oettel, alternative medicine practitioner
Trier


“As a naturopath, I apply the TISSO approach specifically to particularly challenging situations that children and adolescents face. Together, we successfully address the root causes of gastrointestinal problems, allergies, asthma, and food intolerances in my patients, which leads to improved health and well-being.”

Portrait photo of Ulrike Goldberg, a naturopath from Senden
Ulrike Goldberg, alternative medicine practitioner
Send


“To me, TISSO stands for excellent quality ingredients and transparent production of formulations based on the latest scientific findings. TISSO products are an integral part of my holistic treatment approaches and fully meet my standards.”

Portrait photo of Antje Hein, a naturopath from Haby
Antje Hein, alternative medicine practitioner
Haby


“I’ve been using TISSO products for my patients and myself for several years now. I am very happy to have found a company like TISSO that prioritizes proven quality and effectiveness. I have very high standards when it comes to dietary supplements, and thanks to TISSO, I can provide my patients with sound advice and care in this area.”

Portrait photo of Diana Klein, a naturopath from Sprockhövel
Diana Klein, alternative medicine practitioner
Sprockhövel


"I really enjoy working with TISSO. The products are of very high quality, and I’ve had many positive and rewarding experiences with them—both with my patients and for myself. In addition to the products, I appreciate the team behind the company. They’re always helpful, knowledgeable, and friendly. I highly recommend TISSO.”

TISSO.
From practice for people.

That's what makes us special

IN-HOUSE DEVELOPMENT BASED ON SCIENTIFIC RESEARCH

Our experts review countless studies for each formula.

HIGHLY BIOAVAILABLE AND OPTIMALLY COMBINED

We always select our raw materials so that they are as effective as possible.

BRAND-NAME QUALITY FROM OUR OWN PRODUCTION

We manufacture our products ourselves so that we can always guarantee the highest quality.

NUTRITIONAL APPROACH PROVES SUCCESSFUL IN PRACTICE

More than 8,000 doctors and alternative practitioners are already successfully using our holistic MitoBiom® approach.

EXPERTISE SINCE 1999

Take advantage of our extensive experience with high-quality dietary supplements.

GUARANTEE OF THE HIGHEST PURITY

We continuously inspect our products in accordance with the highest quality standards.

FREQUENTLY ASKED QUESTIONS

TISSO Pro Melatonin Depot is a dietary supplement designed to help you fall asleep and stay asleep, as well as to alleviate the subjective symptoms of jet lag. It contains melatonin in a modern sustained-release formulation for immediate and sustained release over several hours—plus chamomile flower extract and reishi powder—a proven combination for peaceful nights and relaxed sleep onset and continuity.

Each Melatonin Depot capsule contains three high-quality ingredients:

  • Extended-release melatonin (melotime™) – A sustained-release formulation that provides both immediate and sustained release of melatonin over several hours
  • Chamomile Flower Extract (Matricaria recutita) – with a relaxing effect that promotes sleep; traditionally enjoyed in the evening
  • Reishi Powder (Ganoderma lucidum) – a time-tested medicinal mushroom from Far Eastern naturopathy – for relaxation and better sleep

Extended-release melatonin, as found in Pro Melatonin Depot, helps improve the ability to fall asleep and stay asleep. It also helps alleviate the subjective symptoms of jet lag when at least 0.5 mg of melatonin is taken shortly before bedtime on the first day of travel and on the first few days after arriving at the destination.

The sustained-release formulation ensures that melatonin is released both immediately and over the course of several hours—providing long-lasting support throughout the night while promoting alertness the following day. Chamomile flowers and reishi naturally complement the formula, promoting relaxation and inner peace—and thus a good night’s sleep.

Take 2 capsules daily, approximately 30–60 minutes before bedtime, with plenty of liquid. Do not exceed the recommended daily dose.

No. Pro Melatonin Depot is not suitable for pregnant women, breastfeeding women, or people under the age of 18.

Yes. If you don't want to swallow the capsules, you can open them and stir the powder into still water, unsweetened herbal teas, or even foods like granola, yogurt, or applesauce. (Please do not add it to hot drinks or foods!)

Just give us a call, Send us an email at info@tisso.de Or send us your question using our contact form. You can reach us here.

CUSTOMER REVIEWS

4.8 Based on 19 reviews

Rating

Carina Buck

Verified Buyer

Delivered quickly - it was recommended to me through a therapy plan. So far satisfied.

Brigitte Eckl

Verified Buyer

Fall asleep faster. Sleep better through the night. 👍🏻

Anne Lessnick

Verified Buyer

The product helps me to fall asleep peacefully in the evening. I am very grateful for that.

Petra Lessner

Verified Buyer

My favorite product for melatonin. Helps me sleep well both when falling asleep and staying asleep. The subscription makes it easy, works great.

Lilly Dangrieß

Verified Buyer

Very satisfied.

Nicole Polster

Verified Buyer

Very good product!

FACT-BASED KNOWLEDGE FOR YOUR HEALTH

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