NeuroBiom Package—Packaging for Pro Biom Anti-Stress, Pro EM san, and Pro Vitamin D3 Öl 1.000
Pro EM san, Pro Biom Anti-Stress, and Pro Vitamin D3 Öl 1.000 alongside saffron threads; features: lactose-free, gluten-free, yeast-free; Image note: AI-assisted content
Easy daily use: “Pro Biom Anti-Stress” using the “nick trick”; “Pro EM san pur” with water or juice; “Pro Vitamin D3 Öl 1.000”: 1 drop per day
What is the NeuroBiom Package for? For mental well-being—the microbiome and brain working together: supports mental health and the nervous system, provides selected bacterial cultures, and delivers daily micronutrients
vegetarian
lactose-free
gluten-free
yeast-free
Tested for harmful substances
additive-free

DIETARY SUPPLEMENTS

NeuroBiom Package

For a Healthy Mind: Your all-in-one package that takes a holistic approach to the microbiome—connecting the gut and the brain—with selected bacterial cultures, saffron, biotin, and vitamins D3, A, and K2. Take advantage of this special package price now!

  • 3-in-1 Package with Pro Biom Anti-Stress, Pro EM san, and Vitamin D3 Oil 1,000
  • For mental well-being—the gut and brain considered together
  • 34 bacterial cultures, including CEREBIOME® and Lactobacillus rhamnosus GG
  • Saffron (Safr’Inside™) and 24 fermented herbs & plants
  • Vitamins D3, A, and K2—plus biotin for mental health and the nervous system
  • Better value than buying individually—exclusively available as a bundle
vegetarian
lactose-free
gluten-free
yeast-free
Tested for harmful substances
additive-free
99,05 €
Tax included. Shipping calculated at checkout.
Product available—delivered to you in 1–4 daysin-house development
Developed in collaboration with therapists

+8,000 doctors and alternative practitioners
See what the therapists have to say

PZN:

Focus on Your Gut and Brain—For Your Mental Well-Being

The TISSO NeuroBiom Package combines Pro Biom Anti-Stress, Pro EM san and Pro Vitamin D3 Öl 1.000 as part of a coordinated approach. The microbiome—or the gut—is closely connected to the brain, which also influences the psyche and mental well-being. Selected bacterial cultures are combined with high-quality saffron and micronutrients such as biotin and vitamins D3, A, and K2. This formula was developed by our in-house scientific team. Get this special package deal now!

Health Claims

  • Biotin contributes to the normal functioning of the nervous system.
  • Biotin contributes to normal mental function.
  • Vitamin A helps maintain normal mucous membranes.

PRODUCTDOSAGERECOMMENDED SERVING SIZE (Please refer to any additional information on the packaging)
PRO BIOM ANTI-STRESS1 capsuleTake with plenty of liquid during or after a meal.
PRO EM SAN1 x 30 ml or 3 x 10 mlTake as is, with plain water or juice, at least half an hour before a meal.
PRO VITAMIN D3 OIL 1,0001 drop (1,000 IU of vitamin D3)Take in the morning with a meal containing fat.


Notes:
Dietary supplements should not be used as a substitute for a balanced and varied diet and a healthy lifestyle.  
Do not exceed the recommended daily intake.

Store in a cool, dry place away from light.

Keep out of the reach of small children.

Please leave the desiccant packet in the can. It contains food-grade silica gel and protects the product from moisture.

Special Notes:

Pro Biom Anti-Stress

Not suitable for pregnant women, nursing mothers, or people under 18 years of age.
Do not consume with other dietary supplements containing saffron.

Pro EM san

Store at room temperature before opening; after opening, store in a cool place at a maximum of 7 °C, protected from light. Swirl the product before opening; do not shake. Once opened, use within approximately 1 month. Store in an upright position and do not drink directly from the bottle. Carbon dioxide buildup may cause slight overpressure in the bottle.

Pro Vitamin D3 Öl 1.000

If you are taking blood thinners (anticoagulants in the vitamin K antagonist class), you should consult a healthcare provider before taking products containing vitamin K.

Pro Biom Anti-Stress Ingredientsper daily dose%NRV*
Bacterial cultures5 x 10⁹ CFU¹-
CEREBIOME®: Lactobacillus helveticus Rosell®-52, Bifidobacterium longum Rosell®-1753 x 10⁹ CFU¹-
Lactobacillus rhamnosus GG2 x 10⁹ CFU¹-
Saffron extract (Safr’Inside™)30 mg-
Biotin7.5 µg15
*Percent of the daily recommended intake, according to the Food Information Regulation (LMIV)
¹colony-forming units (total bacterial count of at least 5 × 10⁹ CFU until the end of the best-by date)
CEREBIOME® is a registered trademark of Danstar Ferment AG.
Safr’Inside™ is a registered trademark of Activ’inside.
Pro EM san Ingredientsper daily dose
Bacterial culturesapprox. 3 × 10¹⁰ CFU*
Herbal and plant blend extract315 mg
Grapefruit seed extract4.9 µl
Ling Zhi (Reishi mushroom)20 mg
Grape seed extract20 mg
Cane sugar0.3 g
Sugar cane molasses0.4 ml
Nutritional values per EM sanper 100 mlper daily dose
Energy25 kJ/6 kcal8 kJ/2 kcal
Fat0 g0 g
of which saturated fatty acids0 g0 g
Carbohydrates1.5 g<0.5 g
of which sugars0.84 g0.25 g
Dietary fiber0.7 g0.2 g
Protein0 g0 g
Salt<0.01 g<0.01 g
*Colony-forming units
Pro Vitamin D3 Öl 1.000 Ingredientsper daily dose%NRV*IU**
Vitamin D3 (cholecalciferol)25 µg5001,000
Vitamin K2 (all-trans MK-7)40 µg53-
Vitamin A (retinyl palmitate)120 µg15400
Sea buckthorn pulp oil1 mg--
*Percent of the recommended daily intake, according to the Food Information Regulation (LMIV)
**International units

Ingredients:

Pro Biom Anti-Stress:
Potato starch; Coating agent: hydroxypropyl methylcellulose; Lactobacillus helveticus Rosell®-52; Bifidobacterium longum Rosell®-175; Lactobacillus rhamnosus GG; Saffron extract (Crocus sativus L.); bulking agent: gum arabic (acacia fiber); antioxidant: L-ascorbic acid; biotin
No flavor enhancers, preservatives, or artificial colors.

According to EM san:
Water; mixture of sugars (sugarcane molasses, cane sugar, malt); sugarcane molasses; cane sugar; herbal and plant extracts (pineapple; angelica root; anise; basil; dill seeds; fennel; rosehip fruit; blueberry leaves; raspberry leaves; elderflower; ginger; olive leaves; oregano; peppermint; rosemary leaves; rooibos; red clover leaves; sage leaves; black cumin seeds; licorice; thyme; grapefruit seed extract; grape seed extract (OPC); Ling Zhi (reishi mushroom); microorganisms
Bacterial cultures contained (approx. 1 • 10¹¹ = 100,000,000,000 bacteria per 100 ml):
1. Bacillus subtilis
2. Bifidobacterium animalis subsp. animalis
3. Bifidobacterium bifidum
4. Bifidobacterium breve
5. Bifidobacterium longum subsp. longum
6. Bifidobacterium longum subsp. infantis
7. Bifidobacterium animalis subsp. lactis
8. Enterococcus lactis
9. Lactobacillus acidophilus
10. Lactobacillus amylolyticus
11. Lactobacillus amylovorus
12. Lactobacillus delbrueckii subsp. bulgaricus
13. Lacticaseibacillus casei 01
14. Lacticaseibacillus casei 02
15. Lacticaseibacillus casei 03
16. Lactobacillus crispatus
17. Lactobacillus delbrueckii
18. Lentilactobacillus farraginis
19. Lactobacillus gasseri
20. Lactobacillus helveticus
21. Lactobacillus johnsonii
22. Lacticaseibacillus paracasei
23. Lentilactobacillus parafarraginis
24. Lactiplantibacillus plantarum
25. Limosilactobacillus reuteri
26. Lacticaseibacillus rhamnosus
27. Ligilactobacillus salivarius
28. Lacticaseibacillus zeae
29. Lactococcus lactis biovar diacetylactis
30. Lactococcus lactis subsp. lactis
31. Streptococcus thermophilus
Contains licorice.
The sugarcane molasses and cane sugar are consumed by the microorganisms during the fermentation process and converted into lactic acid.
Since this is a naturally fermented product, cell counts may vary.
No flavor enhancers, preservatives, or artificial colors.

Pro Vitamin D3 Öl 1.000:
Menachinone (Vitamin K2, all-trans MK-7) (83.4%); coconut-based medium-chain triglyceride oil (MCT oil); sea buckthorn pulp oil; cholecalciferol (3.1%); Retinyl palmitate (0.7%)
No flavor enhancers, preservatives, or artificial colors.

Your legal guarantee rights
LEGAL GUARANTEE Minimum two-year legal guarantee protection for goods sold in the European Union. Consumers can claim their rights under the legal guarantee of conformity, for example if goods: do not match the description; do not function as intended. Sellers are liable for any lack of conformity which existed when the goods were delivered, and which becomes apparent within the legal guarantee period. Sellers in such a situation are required to offer: free repair or free replacement; in some cases, a price reduction or full reimbursement. Some countries have a longer legal guarantee period. For second-hand goods, a shorter period may apply, but not less than one year. For more information on your rights in a specific country, scan the QR code below or ask the seller. europa.eu/youreurope/guarantees What to do if you receive non-conforming goods: 1 Contact the seller as soon as possible to report the issue; 2 Provide proof of purchase, such as a receipt, invoice, or bank statement. Sellers and producers may also offer commercial guarantees, which apply independently from the legal guarantee. For example, you may see this GARAN label representing a commercial guarantee of durability offered by the producer at no additional cost and covering the entire good.

Open the legal guarantee notice on Your Europe

NATURE AND RESEARCH EFFECTIVELY COMBINED
From practice for people.
NATURAL DIETARY SUPPLEMENTS FOR YOUR HEALTH
Eine rothaarige Frau in einem blauen Hemd sitzt mit geschlossenen Augen und zurückgelehntem Kopf entspannt auf einem hellen Sofa, die Hände hinter dem Kopf verschränkt.
Eine rothaarige Frau in einem blauen Hemd sitzt mit geschlossenen Augen und zurückgelehntem Kopf entspannt auf einem hellen Sofa, die Hände hinter dem Kopf verschränkt.

A Holistic Approach – Understanding the Gut-Brain Axis

Our gut is not just the center for nutrient absorption and processing. Through the so-called Gut-Brain Axis It is in constant communication with the brain. Information is transmitted through nerve pathways, hormones, and neurotransmitters, among other means.

Did you know that about 90% of the nerve fibers of the vagus nerve carry information from the gut to the brain, and only about 10% of the signals travel in the opposite direction? An important role in this complex interaction is played by the Gut microbiome with approximately 38 trillion microorganisms. The intestinal mucosa, with its protective mucus layer, is also an important part of the intestine.

Stress and mental strain can affect the gut and digestion. At the same time, an unbalanced diet or changes in the gut flora can also influence this delicate balance.

This is exactly where the NeuroBiom Package It considers mental well-being in the context of the interaction between the microbiome (or gut) and the brain, and to that end combines a wide variety of selected bacterial cultures with saffron and micronutrients such as biotin and vitamins A, D3, and K2.

Well-Being from the Gut—Focus on the Nervous System and Mind

Work-related stress, personal challenges, or prolonged mental strain can place a particularly heavy burden on the nervous system and the mind. Pro Biom Anti-Stress It combines specially selected bacterial cultures with saffron extract and biotin.

Included are CEREBIOME®, which contains the two well-established bacterial strains Lactobacillus helveticus Rosell®-52 and Bifidobacterium longum Rosell®-175, as well as Lactobacillus rhamnosus GG. Together, these bacterial strains provide at least 5 billion CFU (colony-forming units) per daily dose.

It also contains the saffron extract Safr’Inside™ and biotin. Biotin contributes to normal mental function and the normal functioning of the nervous system.

Gut Diversity: Strengthening the Microbial Foundation

Pro EM san adds an exceptionally wide variety of microorganisms to the NeuroBiom Package. The highly concentrated liquid probiotic provides approximately 30 billion CFU (colony-forming units) per daily dose from 31 lactic acid and bifidobacteria cultures. It also contains an extract made from 24 fermented herbs and plants.

What makes the liquid form special is that the microorganisms it contains are “active” and metabolically active. In addition, Pro EM san provides bacterial metabolites produced during the fermentation process.

The The gut microbiome is part of the gut-brain axis, which communicates with the brain through various channels. Thus, the broad bacterial diversity of Pro EM san fits into the holistic NeuroBiom concept.

The "sun vitamin" as a daily staple

Pro Vitamin D3 Öl 1.000 provides high-quality natural Vitamin D3 in a convenient liquid form. Vitamin D3 plays a role in the production of various neurotransmitters. These include, among others, Serotonin, dopamine, and norepinephrine. These are important signaling molecules that work with Mood, Motivation, and Drive are related. The formula also contains vitamin A, which helps maintain normal mucous membranes—including those in the intestines—as well as vitamin K2.

A holistic approach to mental well-being also takes daily micronutrient intake into account. Vitamin D3 intake can become particularly important during months with little sunlight, when spending little time outdoors, or when the body’s needs are increased. With just one drop a day, Pro Vitamin D3 Öl 1.000 can be easily integrated into your daily routine—as a practical micronutrient foundation within the NeuroBiom Package.

Sources

1 Messaoudi et al. 2011. Beneficial psychological effects of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in healthy human volunteers. Gut Microbes, 2(4)

2 Liu, R. T., et al. (2019). Prebiotics and probiotics for depression and anxiety: a systematic review and meta-analysis of controlled clinical trials.

3 Mikola T, Marx W, Lane MM, Hockey M, Loughman A, Rajapolvi S, et al. The effect of vitamin D supplementation on depressive symptoms in adults: A systematic review and meta-analysis of randomized controlled trials. Crit Rev Food Sci Nutr. 2023;63: 11784–11801.

TESTIMONIALS FROM TISSO PARTNERS

Portrait photo of Iwonna Riesenfeld, a naturopath from Düsseldorf
Iwonna Riesenfeld, naturopath
Düsseldorf


“I’ve been working as a naturopath for 15 years, and I’ve been recommending TISSO products for just as long. What continues to impress me time and again is the outstanding quality and the well-thought-out formulation of each product. What’s also truly worth highlighting is that the products are based on the latest scientific findings and take into account our own studies and observational data.”

Portrait photo of Joachim Fehrenbacher, a physical therapist from Schramberg
Joachim Fehrenbacher, Physical Therapist
Schramberg


"Since we take a holistic approach to caring for people, we really enjoy working with TISSO's highly effective products. A trusting partnership of this kind is possible with only a few companies."

Portrait photo of Ailyn Moser, a naturopath from Radolfzell on Lake Constance
Ailyn Moser, naturopath
Radolfzell on Lake Constance


“As a naturopath, I greatly value my collaboration with TISSO, as their work focuses on both our microbiome and our mitochondria. Their holistic dietary supplements combine active ingredients from orthomolecular medicine, phytotherapy, and mycotherapy. For me, TISSO is a reliable partner that supports the health of my patients.”

Portrait photo of Nicole Bode, a naturopath from Höxter
Nicole Bode, alternative medicine practitioner
Höxter


“Products that aren’t just good for my patients, but that I also trust. At TISSO, they take the time to provide detailed advice, which is why I could never do without this partnership! A wide variety of products from alternative practitioners for alternative practitioners, where you can be sure that people’s well-being comes first—not money. I’m happy to stay here and can only recommend it!”

Portrait photo of Andreas Klose, a naturopath from Potsdam
Andreas Klose, alternative practitioner
Potsdam


“I’ve been a naturopath for twenty years and have been working with TISSO products for over seven years. What pleases me most is receiving positive feedback from patients and seeing the results reflected in their test results.”

Portrait photo of Sandra Oettel, a naturopath from Trier
Sandra Oettel, naturopath
Trier


“As a naturopath, I specifically apply the TISSO approach to particularly challenging situations that children and adolescents face. Together, we successfully address the root causes of gastrointestinal problems, allergies, asthma, and food intolerances in my patients, which leads to improved health and well-being.”

Portrait photo of Ulrike Goldberg, a naturopath from Senden
Ulrike Goldberg, alternative medicine practitioner
Send


“To me, TISSO stands for excellent quality ingredients and transparent production of formulations based on the latest scientific findings. TISSO products are an integral part of my holistic therapy approaches and fully meet my high standards.”

Portrait photo of Antje Hein, a naturopath from Haby
Antje Hein, alternative medicine practitioner
Haby


“I’ve been using TISSO products for my patients and myself for several years now. I am very happy to have found a company like TISSO that prioritizes proven quality and effectiveness. I have very high standards when it comes to dietary supplements, and thanks to TISSO, I can provide my patients with sound advice and care in this area.”

Portrait photo of Diana Klein, a naturopath from Sprockhövel
Diana Klein, alternative medicine practitioner
Sprockhövel


“I absolutely love working with TISSO. The products are of very high quality, and I’ve had many positive and rewarding experiences with them—both with my patients and for myself. In addition to the products, I really appreciate the team behind the company. They’re always helpful, knowledgeable, and friendly. I highly recommend TISSO.”

TISSO.
From practice for people.

That's what makes us special

IN-HOUSE DEVELOPMENT BASED ON SCIENTIFIC RESEARCH

Our experts review countless studies for each formula.

HIGHLY BIOAVAILABLE AND OPTIMALLY COMBINED

We always select our raw materials so that they are as effective as possible.

BRAND-NAME QUALITY FROM OUR OWN PRODUCTION

We manufacture our products ourselves so that we can always guarantee the highest quality.

NUTRITIONAL APPROACH PROVES SUCCESSFUL IN PRACTICE

More than 8,000 doctors and alternative practitioners are already successfully using our holistic MitoBiom® approach.

EXPERTISE SINCE 1999

Take advantage of our extensive experience with high-quality dietary supplements.

GUARANTEE OF THE HIGHEST PURITY

We continuously inspect our products in accordance with the highest quality standards.

FREQUENTLY ASKED QUESTIONS

The TISSO NeuroBiom Package combines Pro Biom Anti-Stress, Pro EM san and Pro Vitamin D3 Öl 1.000. The 3-in-1 package combines 34 selected bacterial cultures with saffron, biotin, and vitamins D3, A, and K2. The bacterial cultures support the gut microbiome, which is connected to the brain via the gut-brain axis and is therefore also linked to mental health and well-being.

Pro Biom Anti-Stress Contains CEREBIOME®, Lactobacillus rhamnosus GG, saffron extract, and biotin. Pro EM san Contains 31 bacterial cultures and 24 fermented herbs and plants. Pro Vitamin D3 Öl 1.000 supplements the package with vitamin D3, vitamin A, and vitamin K2.

The NeuroBiom Package combines various components with a focus on the interaction between the gut and the brain. It contains a wide variety of selected bacterial cultures to support the microbiome, as well as saffron and specific micronutrients. Biotin contributes to the normal functioning of the mind and nervous system, and vitamin A helps maintain normal mucous membranes.

The NeuroBiom Package is suitable for adults who want to support their mental health and well-being. It is NOT suitable for people under 18 years of age, nor for pregnant or breastfeeding women.

Pro Biom Anti-Stress Take 1 capsule daily with or after a meal. From Pro EM san The recommended daily dose is 30 ml taken once a day or 3 doses of 10 ml each, preferably on an empty stomach at least 30 minutes before a meal. Pro Vitamin D3 Öl 1.000 Take 1 drop daily, preferably in the morning with a meal containing fat.

The NeuroBiom Package can be supplemented with other TISSO products. Since Pro Biom Anti-Stress Although it already contains saffron extract, it should not be taken together with other dietary supplements that contain saffron. When combining products, be sure to follow the respective consumption and usage instructions for each product.

No. The TISSO NeuroBiom Package is not suitable for pregnant or breastfeeding women, as the included product, Pro Biom Anti-Stress—which contains saffron extract—is not recommended for these groups.

The two products have different areas of focus: Pro Biom Anti-Stress combines three selected bacterial strains, including CEREBIOME®, with saffron and biotin. Pro EM san With 31 bacterial cultures and 24 fermented herbs and plants, it offers an exceptionally wide range of microbial diversity.

Yes, at Pro Biom Anti-Stress You can open the capsules if you don’t want to swallow them. You can stir the contents into still water, unsweetened herbal teas, or even into foods such as granola, yogurt, or applesauce. (Please do not add them to hot beverages or foods!) The other two products in the package—Pro EM san and Pro Vitamin D3 Öl 1.000—are not in capsule form but are liquid products.

Just give us a call, Send us an email at info@tisso.de Or send us your question using our contact form. You can reach us here.

CUSTOMER REVIEWS

4.8
Based on 4348 reviews

Laura Drexler

Verified Buyer

I recommend this product
Really good!
Really good!

Isabella Wedenig

Verified Reviewer

I recommend this product
Working with nature...free from laboratories and manipulations...may the goal remain quality.
The ingredients, herbal composition, selection, very harmonious, genuine, you can still taste the herb itself. Helps immediately, noticeably. Serious and clear processing when ordering, processed with a consciousness for nature right into the hands of the customer. Pro Intest..

Margrit

Verified Reviewer

I recommend this product
Order Processing
Order processing, shipping, and product Pro Mucosa all 100 % 👍👍☺️

Siegfried

Verified Reviewer

I recommend this product
Everything is great
Everything is great, quality, price, performance

Michela Ciuffreda

Verified Buyer

I recommend this product
Maximum precision thanks to Italy
Maximum precision thanks to Italy

Aneta Wozny

Verified Buyer

I recommend this product
Super Product
Super product! Fast delivery

FACT-BASED KNOWLEDGE FOR YOUR HEALTH

READ, LISTEN, UNDERSTAND
Person legt beide Hände auf den nackten Bauch
Product Category
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Nahaufnahme des Auges eines Mannes
Scope of Application
The Nervous System and the Mind
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Podcast
#45 Chronic Stress: The Hidden Risks to Our Gut